Biogenic trypanocidal sesquiterpenes: lead compounds to design future trypanocidal drugs - a mini review
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The trypanocidal activity of naphthoquinones: a review.
Naphthoquinones are compounds present in several families of higher plants. Their molecular structures confer redox properties, and they are involved in multiple biological oxidative processes. In folk medicine, especially among Indian populations, plants containing naphthoquinones have been employed for the treatment of various diseases. The biological redox cycle of quinones can be initiated ...
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26. Wallace, H. M. & Keir, H. M. (1981) HiocAim. Hiophy.~. A m 676.25-30 Wallace, H. M. & Keir, H. M. ( 1986) FE1l.S Lett. 194,hO-63 Wallace, H. M. & Keir. H. M. ( 1985) in R e w i t I'rogrcw in /'o/yamine Hcwcrrch (Selmeci. L.. Hrosnan. M. & Seiler, N.. cds.), pp. 297-304, VNu. The Netherlands Kingsnorth, A. N. & Wallace, H. M. ( 1985) Eirr. J . ( i incer ('/in. Oncol. 21, 1057-1062 Takenoshit...
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A series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity and selectivity as compared with current trypanocidal drug, nifurtimox. Compound 4l exhibit higher selectivity than nifurtim...
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African animal trypanosomosis is arguably the most important animal disease impairing livestock agricultural development in sub-Saharan Africa. In addition to vector control, the use oftrypanocidal drugs is important in controlling the impact of the disease on animal health and production in most sub-Saharan countries. However, there are no internationally agreed standards (pharmacopoeia-type m...
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ژورنال
عنوان ژورنال: DARU Journal of Pharmaceutical Sciences
سال: 2013
ISSN: 2008-2231
DOI: 10.1186/2008-2231-21-35